Regenokine is a rebranding of an old technology called Orthokine. What is it? Well let’s start first with what it’s not. It’s not a stem cell treatment, in fact it’s a serum anti-inflammatory treatment used extensively in the U.S. by large animal veterinarians. In that world, it’s largely been replaced by the much more effective platelet rich plasma (PRP). Why. Orthokine was a great replacement at the time (in the 90s and early 2000s) for steroid anti-inflammatories. Regnokine is made by taking the serum from blood and incubating it with zinc etched glass beads. It’s believed that it’s rich in IRAP (Interleukin 1 Receptor Antagonist Protein) which is a natural anti-inflammatory. There are no growth factors to prompt healing like PRP or stem cells, hence many vets have now moved in the direction of more effective PRP. How effective is Regenokine? IRAP is not very effective for knee osteoarthritis based on the published research.

The upshot? Regenokine is not regenerative, but a natural anti-inflammatory shot that lasts for about 6-9 months and has generally long since been abandoned by U.S. vets for more effective platelet rich plasma. In addition, as I’ve blogged before, the interventional spine standard of care in Europe is much different than in the U.S., so buyer beware!

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